Journal
MECHANISMS OF DEVELOPMENT
Volume 123, Issue 7, Pages 501-512Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2006.05.006
Keywords
endocrine pancreas; development; transcription factor; mouse; fate specification; arx; pax4; diabetes; stem cells
Categories
Funding
- NIDDK NIH HHS [U19 DK 072495-01] Funding Source: Medline
Ask authors/readers for more resources
Cell replacement therapy could represent an attractive alternative to insulin injections for the treatment of diabetes. However, this approach requires a thorough understanding of the molecular switches controlling the specification of the different pancreatic cell-types in vivo. These are derived from an apparently identical pool of cells originating from the early gut endoderm, which are successively specified towards the pancreatic, endocrine, and hormone-expressing cell lineages. Numerous studies have outlined the crucial roles exerted by transcription factors in promoting the cell destiny, defining the cell identity and maintaining a particular cell fate. This review focuses on the mechanisms regulating the morphogenesis of the pancreas with particular emphasis on recent findings concerning the transcription factor hierarchy orchestrating endocrine cell fate allocation. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available