Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 195, Issue 1, Pages 201-207Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2006.01.014
Keywords
preeclampsia; intrauterine growth restriction; uterine artery Doppler; soluble fms-like tyrosine kinase-1
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Objective: The purpose of this study was to evaluate possible relationships between placental markers and endothelial dysfunction in preeclampsia and intrauterine growth restriction. Study design: A prospective study was conducted in 76 patients with preeclampsia and 37 patients with intrauterine growth restriction that were classified as early onset (< 34 weeks of gestational age) or late onset, and 40 control subjects. Plasma levels of placental growth factor, soluble fms-like tyrosine kinase-I, vascular cell adhesion molecule-I, and uterine artery Doppler indices were measured. Results: In early-onset preeclampsia and intrauterine growth restriction, placental growth factor was lower and soluble fms-like tyrosine kinase-I and vascular cell adhesion molecule-I higher than in control subjects, although all changes were more pronounced in preeclampsia. In late-onset preeclampsia, those patients with abnormal uterine artery Doppler indices had higher soluble fms-like tyrosine kinase-I and vascular cell adhesion molecule-I levels. Conclusion: Biochemical changes in early-onset preeclampsia and intrauterine growth restriction point to a common placental disorder and a state of endothelial dysfunction, which may require interaction with other factors to explain the maternal disease in preeclampsia. Data in late-onset preeclampsia suggest that a proportion of them may occur with minimal placental involvement. (c) 2006 Mosby, Inc. All rights reserved.
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