Journal
FREE RADICAL RESEARCH
Volume 40, Issue 7, Pages 665-672Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760600669612
Keywords
oxidative stress; critical illness; antioxidants; ROS
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Massive increase in radical species can lead to oxidative stress, promoting cell injury and death. This review focuses on experimental evidence of oxidative stress in critical illnesses, sepsis and multisystem organ dysfunction. Oxidative stress could negatively affect organ injury and thus overall survival of experimental models. Based on this experimental evidence, we could improve the rationale of supplementation of antioxidants alone or in combination with standard therapies aimed to reduce oxidative stress as novel adjunct treatment in critical care.
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