Journal
JOURNAL OF NEUROSURGERY
Volume 105, Issue 1, Pages 71-74Publisher
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/ped.2006.105.1.71
Keywords
dystonia; baclofen; intrathecal; intraventricular; therapy; pediatric neurosurgery
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Two children with generalized dystonia were given continuous intraventricular baclofen (IVB) infusions. The first was a 12-year-old girl with mixed dystonia and spasticity caused by methylmalonic aciduria whose spinal anatomy precluded administration of intrathecal baclofen (ITB). The second was an 11-year-old boy whose dystonia was associated with cerebral palsy and had not improved significantly in response to conventional ITB treatment. The girl improved dramatically with IVB; the boy experienced no greater improvement from IVB than from ITB. No adverse effects were noted in either child during 2 to 6 months of infusion. These are the first reports of the use of IVB in this clinical setting. The results warrant additional investigation.
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