Journal
BIOPHYSICAL JOURNAL
Volume 91, Issue 1, Pages 179-188Publisher
CELL PRESS
DOI: 10.1529/biophysj.105.079046
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Funding
- NIDCD NIH HHS [R01 DC00926, F31 DC006121, R01 DC000926] Funding Source: Medline
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Olfactory cilia contain the known components of olfactory signal transduction, including a high density of cyclicnucleotide-gated (CNG) channels. CNG channels play an important role in mediating odor detection. The channels are activated by cAMP, which is formed by a G-protein-coupled transduction cascade. Frog olfactory cilia are 25 - 200 mu m in length, so the spatial distribution of CNG channels along the length should be important in determining the sensitivity of odor detection. We have recorded from excised cilia and modeled diffusion of cAMP into a cilium to determine the spatial distribution of the CNG channels along the ciliary length. The proximal segment, which in frog is the first 20% of the cilium, appears to express a small fraction of the CNG channels, whereas the distal segment contains the majority, mostly clustered in one region.
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