Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 27, Issue 7, Pages 375-383Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2006.05.003
Keywords
-
Categories
Ask authors/readers for more resources
The concentration of neurotransmitters in the extracellular space is tightly controlled by distinct classes of membrane transport proteins. This review focuses on the molecular function of two major classes of neurotransmitter transporter that are present in the cell membrane of neurons and/or glial cells: the solute carrier (SLC)1 transporter family, which includes the transporters that mediate the Na+-dependent uptake of glutamate, and the SLC6 transporter family, which includes the transporters that mediate the Na+-dependent uptake of dopamine, 5-HT, norepinephrine, glycine and GABA. Recent research has provided substantial insight into the structure and function of these transporters. In particular, the recent crystallizations of bacterial homologs are of the utmost importance, enabling the first reliable structural models of the mammalian neurotransmitter transporters to be generated. These models should be an important tool for developing specific drugs that, through selective interaction with transporters, could improve the treatment of serious neurological and psychiatric disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available