Antitumor active monofunctional platinum(II) complexes: Synthesis, structural characterization and reactivity towards biomolecules

Monofunctional platinum(II) complexes represent a class of antitumor agents that do not obey the classical structure-activity relationships. We report herein two novel platinum(II) complexes [PtL1Cl] (L-1 = L-valine-N-8-quinolylamide) and [PtL2Cl] (L-2 = L-leucine-N-8-quinolylamide) in which Cl- acts as the only potential leaving group. These complexes showed comparable cytotoxicity to cisplatin against the murine leukemia cell line (P-388) and the human non-small-cell lung cancer cell line (A-549), and could potentially form monofunctional adducts with DNA. (C) 2006 Elsevier B.V. All rights reserved.