Journal
MOLECULAR PSYCHIATRY
Volume 11, Issue 7, Pages 633-648Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.mp.4001835
Keywords
DNA microarray; gene expression; RGS4; somatostatin; neuropeptide Y; tachykinin 1; RT qPCR; BDNF; in situ hybridization
Funding
- NIMH NIH HHS [R01 MH067234, K02 MH070786, 2 P50 MH45156-14] Funding Source: Medline
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Brain-derived neurotrophic factor ( BDNF) has been reported to be critical for the development of cortical inhibitory neurons. However, the effect of BDNF on the expression of transcripts whose protein products are involved in gamma amino butric acid ( GABA) neurotransmission has not been assessed. In this study, gene expression profiling using oligonucleotide microarrays was performed in prefrontal cortical tissue from mice with inducible deletions of BDNF. Both embryonic and adulthood ablation of BDNF gave rise to many shared transcriptome changes. BDNF appeared to be required to maintain gene expression in the SST-NPY-TAC1 subclass of GABA neurons, although the absence of BDNF did not alter their general phenotype as inhibitory neurons. Furthermore, we observed expression alterations in genes encoding early-immediate genes ( ARC, EGR1, EGR2, FOS, DUSP1, DUSP6) and critical cellular signaling systems ( CDKN1c, CCND2, CAMK1g, RGS4). These BDNF-dependent gene expression changes may illuminate the biological basis for transcriptome changes observed in certain human brain disorders.
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