Journal
ELECTROPHORESIS
Volume 27, Issue 13, Pages 2814-2818Publisher
WILEY
DOI: 10.1002/elps.200500911
Keywords
Alzheimer's disease; mitochondria; Parkinson's disease; proteome; two-dimensional gel electrophoresis
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Alterations in mitochondrial structure or function have been described in a variety of human diseases for nearly half a century. The complete sequence of the human mitochondrial genome has been published in 1981. The mitochondrial proteome database however, is still incomplete. Here I give a short review on recent advances to determine the complete set of mitochondrial proteins. The main emphasis is put on gel-based proteomic approaches to identify differentially expressed mitochondrial proteins in neurodegenerative diseases.
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