Journal
MICROBES AND INFECTION
Volume 8, Issue 8, Pages 2299-2304Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2006.03.014
Keywords
toll-like receptor; Candida albicans; murine candidiasis; TNF-alpha; IFN-gamma; IL-12p70
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Toll-like receptors (TLRs) function as sensors for infection that induce the activation of the immune responses. Recent studies have demonstrated a crucial involvement of TLRs in the recognition of fungal pathogens such as Candida albicans. Although both TLR2 and TLR4 have been implicated in the host interaction with C. albicans, their specific role during infection has not been unequivocally established, as conflicting results have been reported. In this review, we summarize and discuss our own and others' key findings about the specific role of TLR2 and TLR4 in murine resistance to candidiasis, and in triggering cytokine secretion by murine cells in response to C. albicans yeasts and hyphae. (c) 2006 Elsevier SAS. All rights reserved.
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