Journal
LANCET
Volume 368, Issue 9529, Pages 83-86Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(06)68971-X
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There are many reasons why the dietary-heart-cholesterol hypothesis should be questioned, and why statins might be acting in some other way to reduce the risk of coronary heart disease. Here, I propose that rather than being cholesterol-lowering drugs per se, statins act as vitamin D analogues, and explain why. This proposition is based on published observations that the unexpected and unexplained clinical benefits produced by statins have also been shown to be properties of vitamin D. It seems likely that statins activate vitamin D receptors.
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