Amyloid load and cerebral atrophy in Alzheimer's disease:: An 11C-PIB positron emission tomography study

To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. C-11-PIB(C-11-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional C-11-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.