Journal
ANNALS OF NEUROLOGY
Volume 60, Issue 1, Pages 145-147Publisher
WILEY-LISS
DOI: 10.1002/ana.20889
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Funding
- Medical Research Council [G84/6523, MC_U120036861] Funding Source: Medline
- Alzheimers Research UK [ART-PPG2004A-3] Funding Source: researchfish
- Medical Research Council [MC_U120036861, G84/6523] Funding Source: researchfish
- MRC [MC_U120036861, G84/6523] Funding Source: UKRI
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To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. C-11-PIB(C-11-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional C-11-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.
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