Journal
BRAIN AND COGNITION
Volume 61, Issue 2, Pages 189-194Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandc.2005.12.012
Keywords
near-infrared spectroscopy; Alzheimer's disease; mild cognitive impairment; hemoglobin oxygenation; quantitative method; primary screening
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A newly developed quantitative near-infrared spectroscopy (NIRS) system was used to measure changes in cortical hemoglobin oxygenation during the Verbal Fluency Task in 32 healthy controls, 15 subjects with mild cognitive impairment (MCI), and 15 patients with Alzheimer's disease (AD). The amplitude of changes in the waveform, which was quantitatively calculated by a signal processing method, was significantly lower in the frontal, and the bilateral parietal areas in the AD group, whereas that in the MCI group was significantly lower only in the right parietal area. The NIRS system may be a potential tool for the primary screening of AD. (c) 2005 Elsevier Inc. All rights reserved.
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