Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 54, Issue 7, Pages 1046-1049Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.54.1046
Keywords
liverwort; Radula appressa; Thysananthus spathulistipus; clerodane; prenylated bibenzyl; nitric oxide
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3 beta,4 beta:15,16-Diepoxy-13(16),14-clerodadiene (1) and a new clerodane diterpenoid designated thysaspathone (2) were isolated from the liverwort Thysananthus spathulistipus, while Radula appressa produced radulannin A (3), radulannin L (4), 2-geranyl-3,5-dihydroxybibenzyl (5), 2(S)-2-methyl-2-(4-methyl-3-pentenyl)-7-hydroxy-5-(2-phenylethyl) chromene (o-cannabichromene) (6), 6-hydroxy-4-(2-phenylethyl) benzofuran (7), and o-cannabicyclol (8). All of the isolated compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the greatest inhibition was attributed to compound 5, with an IC50 value of 4.5 mu m.
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