Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 41, Issue 7, Pages 825-832Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2006.02.006
Keywords
1 beta-methylcarbapenems; antibacterial activity; substiment effects
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The synthesis of a new series of 1 beta-methylcarbapenems having cyclic thiourea moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIId) having piperazine thiourea moiety showed the most potent antibacterial activity. (c) 2006 Elsevier SAS. All rights reserved.
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