Journal
CELL RESEARCH
Volume 16, Issue 7, Pages 661-670Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/sj.cr.7310069
Keywords
LXR; beta-cells; insulin secretion; glucose uptake; subcellular localization
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Liver X receptors (LXRs) are members of the nuclear receptor superfamily, which have been implicated in lipid homeostasis and more recently in glucose metabolism. Here, we show that glucose does not change LXR alpha protein level, but affects its localization in pancreatic beta-cells. LXR alpha is found in the nucleus at 8 mM glucose and in the cytoplasm at 4.2 mM. Addition of glucose translocates LXRa from the cytoplasm into the nucleus. Moreover, after the activation of LXR by its synthetic non-steroidal agonist (T0901317), insulin secretion and glucose uptake are increased at 8 mM and decreased at 4.2 nM glucose in a dose-dependent manner. Furthermore, at low glucose condition, okadaic acid reversed LXR alpha effect on insulin secretion, suggesting the involvement of glucose signaling through a phosphorylation-dependent mechanism.
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