Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 11, Issue 4, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.2220527
Keywords
tissues; optical properties; collagen; lasers
Funding
- NCRR NIH HHS [RR01192] Funding Source: Medline
- NIAMS NIH HHS [AR048458, AR047551] Funding Source: Medline
- NIBIB NIH HHS [EB002495, EB004846] Funding Source: Medline
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Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations. (c) 2006 Society of Photo-Optical Instrumentation Engineers.
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