Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 118, Issue 1, Pages 178-189Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2006.03.047
Keywords
atopic dermatitis; immunity; pruritus; lymphocyte; trafficking
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Atopic dermatitis (AD) is a common pruritic and chronically relapsing inflammatory skin disease. The pathophysiology of AD includes disturbed skin barrier functions, frequent allergic responses against allergens, defects in the antimicrobial immune defense, and a genetic predisposition. In this review we summarize advances in our understanding of the complex interdependent network of members of the rapidly growing protein superfamilies of cytokines and chemokines that lead to the development of AD.
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