Journal
JOURNAL OF VIROLOGY
Volume 80, Issue 13, Pages 6697-6701Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02388-05
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Funding
- Medical Research Council [MC_U137884185] Funding Source: Medline
- Medical Research Council [MC_U137884185] Funding Source: researchfish
- MRC [MC_U137884185] Funding Source: UKRI
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Six of seven HLA-A*2402-positive individuals with acute parvovirus B19 infections made vigorous CD8-positive cytotoxic T-cell (CTL) responses to the viral epitope FYTPLADQF. All responders showed highly focused T-cell receptor (TCR) usage, using almost exclusively BV5.1. The BV5.1 TCR dominated the acute response, was maintained over time, and was also used by a remotely infected individual. Nine CTL clones and two oligoclonal lines obtained from three unrelated individuals used BV5.1, BJ2.1, and a conserved TCR CDR3 of nine amino acids. This commonly recognized epitope is likely important in long-term protective immunity and should be included in vaccine design.
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