Journal
FEMS MICROBIOLOGY REVIEWS
Volume 30, Issue 4, Pages 564-595Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6976.2006.00023.x
Keywords
Acanthamoeba; encephalitis; keratitis; epidemiology; pathogenesis; disease
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Acanthamoeba is an opportunistic protozoan that is widely distributed in the environment and is well recognized to produce serious human infections, including a blinding keratitis and a fatal encephalitis. This review presents our current understanding of the burden of Acanthamoeba infections on human health, their pathogenesis and pathophysiology, and molecular mechanisms associated with the disease, as well as virulence traits of Acanthamoeba that may be targets for therapeutic interventions and/or the development of preventative measures.
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