Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 17, Issue 5, Pages 205-215Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2006.05.006
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Adenosine 5' monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. It mediates some of the effects of peripheral hormones such as leptin, ghrelin and adiponectin, and it is involved in the insulin-sensitizing role of the antidiabetic drug metformin. There is increasing evidence that AMPK has a central role in mediating the appetite-modulating and metabolic effects of many other hormones and substances, including the cannabinoids. Recent studies have illustrated the interaction between hormones and AMPK, and highlighted AMPK as a potential target for the development of tissuespecific AMPK modulators in the treatment of obesity and the metabolic syndrome.
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