Journal
ANNALS OF NEUROLOGY
Volume 73, Issue 4, Pages 554-559Publisher
WILEY-BLACKWELL
DOI: 10.1002/ana.23817
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Funding
- Australian Research Council
- Australian National Health and Medical Research Council
- CRC for Mental Health
- Victorian State Government
- University of Melbourne
- Mental Health Research Institute
- Alfred Hospital
- Victorian Forensic Institute of Medicine
- Neurosciences Australia
- National Health and Medical Research Council
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Ceruloplasmin is an iron-export ferroxidase that is abundant in plasma and also expressed in glia. We found a approximate to 80% loss of ceruloplasmin ferroxidase activity in the substantia nigra of idiopathic Parkinson disease (PD) cases, which could contribute to the pro-oxidant iron accumulation that characterizes the pathology. Consistent with a role for ceruloplasmin in PD etiopathogenesis, ceruloplasmin knockout mice developed parkinsonism that was rescued by iron chelation. Additionally, peripheral infusion of ceruloplasmin attenuated neurodegeneration and nigral iron elevation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model for PD. These findings show, in principle, that intravenous ceruloplasmin may have therapeutic potential in PD. Ann Neurol 2013;73:554-559
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