Journal
CANCER BIOLOGY & THERAPY
Volume 5, Issue 7, Pages 760-762Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cbt.5.7.3103
Keywords
APC/C; ubiquitin; E3 ligase; CBP; p300; E1A; transcription; transformation; cell cycle progression
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APC/C complex has been known to regulate cell cycle progression via its ubiquitin E3 ligase activity that targets a number of cell cycle regulators. In a recent report, it is shown that APC/C interacts with transcription co-activators, CBP and p300, via its APC5 and APC7 subunits.(1) The authors further demonstrate the functional significance of APC/C-CBP/p300 interaction in regulating both transcription and cell cycle progression. These findings have profound implications in unveiling additional functions and regulatory mechanisms of these two seemingly independent molecular modulators.
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