Journal
JOURNAL OF IMMUNOLOGY
Volume 177, Issue 1, Pages 31-35Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.177.1.31
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A powerful IFN-gamma response is triggered upon infection with the protozoan parasite, Toxoplasma gondii. Several cell populations, including dendritic cells (DO), macrophages, and neutrophils, produce IL-12, a key cytokine for IFN-gamma induction. However, it is still unclear which of the above cell populations is its main source. Diphtheria toxin (D T) injection causes transient DC depletion in a transgenic mouse expressing Simian DT receptors under the control of the CD11c promoter, allowing us to investigate the role of DCs in IL-12 production. T. gondii-inoculated DT-treated and control groups were monitored for IL-12 levels and survival We show in this study that DC depletion abolished IL-12 production and led to mortality. Furthermore, replenishment with wild-type, hut not MyD88- or IL-12p35-deficient, DCs rescued IL-12 production, IFN-gamma-induction, and resistance to infection in DC-depleted mice. Taken together, the results presented in this study indicate that DCs constitute the major IL12-producing cell population in vivo during T. gondii infection.
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