Journal
ANNALS OF NEUROLOGY
Volume 73, Issue 1, Pages 136-139Publisher
WILEY-BLACKWELL
DOI: 10.1002/ana.23763
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Funding
- German ministry of research (BMBF) [01 EO 0801]
- Einstein Foundation
- German research organization (DFG) [TR43, KFO 247, KFO 213]
- European Union (European Stroke Network)
- Volkswagen Foundation, Lichtenberg Program
- Corona Foundation
- Boehringer Ingelheim
- SANOFI
- Bayer
- AstraZeneca
- Novartis
- Maquet
- Berlin Chemie
- Bristol-Myers Squibb
- Desitin
- Eisei
- Ever
- GlaxoSmithKline
- MSD
- Takeda
- Trommsdorff
- Siemens
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Temporal delay in blood oxygenation level-dependent (BOLD) signals may be sensitive to perfusion deficits in acute stroke. Resting-state functional magnetic resonance imaging (rsfMRI) was added to a standard stroke MRI protocol. We calculated the time delay between the BOLD signal at each voxel and the whole-brain signal using time-lagged correlation and compared the results to mean transit time derived using bolus tracking. In all 11 patients, areas exhibiting significant delay in BOLD signal corresponded to areas of hypoperfusion identified by contrast-based perfusion MRI. Time delay analysis of rsfMRI provides information comparable to that of conventional perfusion MRI without the need for contrast agents. ANN NEUROL 2013;73:136-139.
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