Journal
TRENDS IN MICROBIOLOGY
Volume 14, Issue 7, Pages 294-298Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2006.05.001
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The Gram-positive bacterium Listeria monocytogenes uses a wide range of virulence factors for its pathogenesis. Expression of five of these factors has previously been shown to be subjected to post-transcriptional regulation as a result of their long W-untranslated region (5-UTR). We have investigated the presence of 5'-UTRs among the other known virulence genes and genes that encode putatively virulence-associated surface proteins. Our results strongly suggest that L. monocytogenes controls many of its virulence genes by a mechanism that involves the 5-UTR. These findings further emphasize the importance of post-transcriptional control for L. monocytogenes virulence.
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