Journal
JOURNAL OF IMMUNOLOGY
Volume 177, Issue 1, Pages 246-254Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.177.1.246
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CD4(+)CD25(+) regulatory T (T-R) cells suppress effector T cells by partly unknown mechanisms.' In this study, we describe a population of human suppressive CD4(+)CD25(+) adaptive TR (TR adapt) cells induced in vitro that express cyclooxygenase 2 (COX-2) and the transcription factor FOXP3. TRadapt cells produce PGE(2) and suppress effector T cell responses in a manner that is reversed by COX inhibitors and PGE2 receptor-specific antagonists. In resting CD4(+)CD25(-) T cells, treatment with PGE2 induced FOXP3 expression. Thus, autocrine and paracrine effects of PGE(2) produced by COX-2-positive T-R(adapt) cells may be responsible for both the FOXP3(+) phenotype and the mechanism used by these cells to suppress effector T cells.
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