Journal
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
Volume 20, Issue 3, Pages 127-132Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002093-200607000-00001
Keywords
Alzheimer disease; amyloid-beta peptide; antibody avidity; tolerance
Categories
Ask authors/readers for more resources
Some studies have indicated that low level of anti-A antibodies may play an important role in the pathogenesis of Alzheimer disease (AD), but little is known about the avidity of these antibodies. We investigated the avidity and levels of anti-A beta antibodies in 20 AD patients and 40 healthy controls by an enzyme-linked immunosorbent assay with thiocyanate elution. Our data revealed that both the levels and the avidity of anti-A beta antibodies were statistically lower in AD patients than in healthy controls. However, there was no correlation between both of them. suggesting that the levels and the avidity of anti-A beta antibodies might be regulated by different mechanisms. We hypothesize that incomplete B cell immune tolerance may be the major reason for low antibody avidity in AD patients. Avidity declination in AD patients should have immunopathologic implications as antigen-antibody complexes containing low avidity antibodies are not readily cleared by the immune system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available