Journal
NEUROPHARMACOLOGY
Volume 51, Issue 1, Pages 44-51Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2006.02.014
Keywords
nicotine; DeltaFosB; c-Fos; nucleus accumbens; caudate-putamen; sensitization
Categories
Ask authors/readers for more resources
Delta FosB, a member of Fos family of transcription factors, is implicated in behavioural responses and synaptic plasticity induced by abused drugs. We studied the expressions of FosB/Delta FosB and c-Fos immunohistochemically in two dopaminergic brain areas, nucleus accumbens (NAcc) and caudate-putamen (CPu). In mice neither 2- nor 7-week oral nicotine treatment induced expression of long-lived Delta FosB isoforms although during the treatment in the NAcc FosB/Delta FosB expression was increased as was c-Fos in the CPu. In rats given nicotine subcutaneously once daily for 5 days FosB/Delta FosB expression was elevated in the NAcc still after 24-h withdrawal suggesting accumulation of Delta FosB but in the CPu neither FosB/Delta FosB nor c-Fos expression was altered. Thus, in rats repeated nicotine administration seems mainly affect the NAcc paralleling with the evidence that nicotine stimulates preferentially mesolimbic dopamine system. Also, repeated nicotine induced behavioural sensitization in rats agreeing with suggested role of Delta FosB in the development of psychomotor sensitization. However, in mice given nicotine via drinking fluid although striatal fosB and c-fos were activated by nicotine even after 7-week treatment no evidence of accumulation of long-lived Delta FosB was found suggesting perhaps a species difference or more likely a role for the manner of administration. (c) 2006 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available