Journal
ANNALS OF NEUROLOGY
Volume 72, Issue 1, Pages 144-147Publisher
WILEY-BLACKWELL
DOI: 10.1002/ana.23571
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Funding
- BBSRC Pfizer CASE studentship
- Oxfordshire Health Services Research Committee
- Biomedical Research Centre Oxford
- British Heart Foundation
- OUP
- Oxford Charitable Funds
- National Institute for Health Research [CL-2007-13-011] Funding Source: researchfish
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Most of the time the bladder is locked in storage mode, switching to voiding only when it is judged safe and/or socially appropriate to urinate. Here we show, in humans and rodents, that deep brain stimulation in the periaqueductal gray matter can rapidly and reversibly manipulate switching within the micturition control circuitry, to defer voiding and maintain urinary continence, even when the bladder is full. Manipulation of neural continence pathways by deep brain stimulation may offer new avenues for the treatment of urinary incontinence of central origin. ANN NEUROL 2012;72:144-147
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