4.7 Article

Naturally occurring extended-spectrum cephalosporinases in Escherichia coli

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 50, Issue 7, Pages 2573-2576

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01633-05

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Genetic and functional characterization of the cephalosporinases produced by 65 clonally unrelated clinical Escherichia coli isolates revealed genetic diversity of the ampC genes and showed that GIn287, Cys287, Pro296, Leu298, and Phe350 substitutions were involved in extension of the hydrolysis spectrum to include ceftazidime and cefepime.

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