Journal
TRENDS IN CELL BIOLOGY
Volume 16, Issue 7, Pages 351-361Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2006.05.003
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Funding
- Intramural NIH HHS Funding Source: Medline
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Phosphoinositides account for only a tiny fraction of cellular phospholipids but are extremely important in the regulation of the recruitment and activity of many signaling proteins in cellular membranes. Phosphatidylinositol (PtdIns) 4-kinases generate PtdIns 4-phosphate, the precursor of important regulatory phosphoinositides but also an emerging regulatory molecule in its own right. The four mammalian PtdIns 4-kinases regulate a diverse array of signaling events, as well as vesicular trafficking and lipid transport, but the mechanisms by which their lipid product PtdIns 4-phosphate controls these processes is only beginning to unfold.
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