Journal
DRUG DELIVERY
Volume 13, Issue 4, Pages 245-251Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717540500313067
Keywords
drug delivery; hydrogels; nanoparticles; N-isopropylacrylamide; pH sensitive; thermoresponsive
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The present work is focused on investigating the controlled drug release behavior of Poly [N-isopropylacrylamide-co-2-Hydroxyethylacrylate] (P [NIPAm-HEAc])- based hydrogel. The synthesis process includes the preparation of monodispersed hydrogel nanoparticles containing specific functional groups, followed by cross-linking to neighboring spheres to stabilize the entire network. The color and volume of these crystalline hydrogel networks can reversibly change in response to external stimuli such as temperature, pH, and other environmental conditions. The feasibility of the hydrogel as a controlled release vehicle for 5-fluorouracil is evaluated.
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