Journal
ANNALS OF NEUROLOGY
Volume 70, Issue 6, Pages 871-880Publisher
WILEY
DOI: 10.1002/ana.22516
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Funding
- NIA NIH HHS [K23 AG028726, P50 AG005134] Funding Source: Medline
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Cerebral amyloid angiopathy (CAA) results from deposition of beta-amyloid in the media and adventitia of small arteries and capillaries of the leptomeninges and cerebral cortex and is a major cause of lobar intracerebral hemorrhage and cognitive impairment in the elderly. CAA is associated with a high prevalence of magnetic resonance imaging markers of small vessel disease, including cerebral microbleeds and white matter hyperintensities. Although advanced CAA is present in approximately 1/4 of brains with Alzheimer disease (AD), fewer than half of CAA cases meet pathologic criteria for AD. This review will discuss the pathophysiology of CAA and focus on new imaging modalities and laboratory biomarkers that may aid in the clinical diagnosis of individuals with the disease. ANN NEUROL 2011;70:871880
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