Journal
ANNALS OF NEUROLOGY
Volume 70, Issue 5, Pages 822-837Publisher
WILEY-BLACKWELL
DOI: 10.1002/ana.22535
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Funding
- Department of Health's National Institute for Health Research Biomedical Research Center
- UK Medical Research Council [G0301067]
- Bundesministerium fur Bildung und Forschung [01 EV 0703]
- Deutsche Forschungsgemeinschaft [LA 1452/3-1]
- Swiss National Science Foundation [33CM30-124089]
- Fonds de Perfectionnement of the University Hospital of Geneva, Switzerland
- Wellcome Trust [067176]
- Medical Research Council [G9805089]
- Epilepsy Society
- Wellcome Trust
- MRC [G0301067] Funding Source: UKRI
- Medical Research Council [G0200216, G0301067] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0509-10161] Funding Source: researchfish
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Objective: Surgical treatment of focal epilepsy in patients with focal cortical dysplasia (FCD) is most successful if all epileptogenic tissue is resected. This may not be evident on structural magnetic resonance imaging (MRI), so intracranial electroencephalography (icEEG) is needed to delineate the seizure onset zone (SOZ). EEG-functional MRI (fMRI) can reveal interictal discharge (IED)-related hemodynamic changes in the irritative zone (IZ). We assessed the value of EEG-fMRI in patients with FCD-associated focal epilepsy by examining the relationship between IED-related hemodynamic changes, icEEG findings, and postoperative outcome.
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