Journal
NATURE NEUROSCIENCE
Volume 9, Issue 7, Pages 868-869Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1713
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Funding
- NIDA NIH HHS [1R01DA15096-01] Funding Source: Medline
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The core and shell of the nucleus accumbens have critical, differential roles in drug-dependent behaviors. Here we show that operant cocaine self-administration inhibits long-term depression ( LTD) in both structures after 1 d of abstinence. However, after 21 d of abstinence, LTD was abolished exclusively in the nucleus accumbens core of cocaine self-administering rats, suggesting that voluntary cocaine self-administration induced long- lasting neuroadaptations in the core that could underlie drug-seeking behavior and relapse.
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