Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 16, Issue 13, Pages 3600-3604Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.03.068
Keywords
oxazolidinone; RNA; fluorescence
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Funding
- NIGMS NIH HHS [GM61048] Funding Source: Medline
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We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones. (c) 2006 Elsevier Ltd. All rights reserved.
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