Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 118, Issue 1, Pages 202-208Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2006.04.033
Keywords
atopic dermatitis; eczema; innate immunity
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Funding
- NIAID NIH HHS [R01 AI045839, N01 AI 40029] Funding Source: Medline
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Atopic dermatitis (AD) is a common, chronic inflammatory skin disease that becomes clinically apparent in the pediatric population. It is well recognized that subjects with AD have an increased susceptibility to cutaneous colonization and infection with bacteria, fungi, and viruses. The notion that subjects with AD have a cutaneous immune defect has received widespread acceptance, and several plausible explanations for this have been proposed. We will review the evidence that this susceptibility to cutaneous infection is at least in part due to a defect in the first line of defense against microbes, namely the innate immune system.
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