Journal
PROTEOMICS
Volume 6, Issue 14, Pages 3993-4015Publisher
WILEY
DOI: 10.1002/pmic.200600129
Keywords
glycomics; glycoproteomics; glycosylation; diseases; oligosaccharides
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Of all protein PTMs, glycosylation is by far the most common, and is a target for proteomic research. Glycosylation plays key roles in controlling various cellular processes and the modifications of the glycan structures in diseases highlight the clinical importance of this PTM. Glycosylation analysis remains a difficult task. MS, in combination with modem separation methodologies, is one of the most powerful and versatile techniques for the structural analysis of glycoconjugates. This review describes methodologies based on MS for detailed characterization of glycoconjugates in complex biological samples at the sensitivity required for proteomic work.
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