Journal
DEVELOPMENTAL DYNAMICS
Volume 235, Issue 7, Pages 1941-1952Publisher
WILEY
DOI: 10.1002/dvdy.20799
Keywords
delta EF1; Sip1; Zfhx1 family; Sox2; neural plate; craniofacial development
Categories
Ask authors/readers for more resources
In mouse embryos, the Zfhx1 transcription factor genes, Sip1 and delta EF1, are expressed in complementary domains in many tissues. Their possible synergism in embryogenesis was investigated by comparing the phenotype of Sip1-/-;delta EF1-/- double homozygotes with single homozygous embryos. Unexpectedly, in Sip1-/- embryos delta EF1 was ectopically activated, suggesting a negative regulation of delta EF1 expression by Sip1. Sip1-/-;delta EF1-/- embryos were similar to Sip1-/- embryos in short somite production and developmental arrest around E8.5, but showed more severe defects in dorsal neural tube morphogenesis accompanied by a larger reduction of Sox2 expression, ascribable to the loss of the ectopic delta EF1 expression. Sip1+/-;delta EF1-/- embryos develop various morphological defects after E10 that were absent in delta EF1-/- embryos even in tissues without significant overlap of Sip1 and delta EF1 expression, and arrested during mid gestation earlier than delta EF1-/- embryos. These findings indicate that complex synergistic interactions occur between Zfhx1 transcription factor genes during mouse embryogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available