Journal
BRAIN & DEVELOPMENT
Volume 28, Issue 6, Pages 405-409Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.braindev.2005.12.003
Keywords
unilateral polymicrogyria; hemiplegia; fMRI; diffusion tensor imaging; fiber tracking; corticospinal tract
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We examined the fiber organization of the brain in three patients with unilateral polymicrogyria (PMG) using diffusion tensor imaging (DTI) in combination with functional magnetic resonance imaging (fMRI). DTI revealed altered fiber tract architecture in patients with PMG. Long projection fibers, such as the corticospinal tract, were reduced the most, whereas long association fibers were less affected. The diminution of the fiber tracts was relevant to the loss of functionality of the PMG-affected cortex. Our preliminary study suggests that the combination of DTI and fMRI reinforces the clinical assessment of functionality in PMG. (c) 2006 Elsevier B.V. All rights reserved.
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