Journal
ANNALS OF NEUROLOGY
Volume 68, Issue 4, Pages 545-548Publisher
WILEY
DOI: 10.1002/ana.22099
Keywords
-
Categories
Funding
- National Institutes of Health [R01 AG026484]
- Alzheimer's Association [IIRG-06-26331]
- Harvard NeuroDiscovery Center (HNDC)
Ask authors/readers for more resources
Advanced cerebrovascular beta-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2(star)-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition. ANN NEUROL 2010;68:545-548
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available