Journal
PEDIATRIC CRITICAL CARE MEDICINE
Volume 7, Issue 4, Pages 380-382Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.PCC.0000225000.78627.EB
Keywords
premature infants; pulmonary hypertension; nitric oxide; high-frequency ventilation
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Objectives: To use intravenous adenosine as a rescue therapy for neonatal refractory pulmonary hypertension in a low-weight premature infant. Study Line: We report the successful use of a continuous intravenous adenosine infusion in a 1150-g premature baby with severe persistent pulmonary hypertension, refractory to classic management with high-frequency oscillatory ventilation, oxygen therapy and inhaled nitric oxide. Results: Adenosine infusion had a dramatic effect allowing for a rapid weaning of oxygen, ventilatory variables, and nitric oxide. Conclusions: Although experience with continuous adenosine infusion is still at an early stage, it might be worth considering its administration as a rescue therapy or even as an alternative to extracorporeal membrane oxygenation.
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