Journal
ANNALS OF NEUROLOGY
Volume 68, Issue 4, Pages 535-540Publisher
WILEY
DOI: 10.1002/ana.22015
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Funding
- Department of Health for the Commonwealth of Pennsylvania
- Elan-Wyeth
- Brystol Myers Squibb
- NIH
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To determine the impact of cortical Alzheimer disease pathology on shunt responsiveness in individuals treated for idiopathic normal pressure hydrocephalus (iNPH), 37 patients clinically diagnosed with iNPH participated in a prospective study in which performance on neurologic, psychometric, and gait measures before and 4 months after shunting was correlated with amyloid plaques, neuritic plaques, and neurofibrillary tangles observed in cortical biopsies obtained during shunt insertion. No complications resulted from biopsy acquisition. Moderate to severe pathology was associated with worse baseline cognitive performance and diminished postoperative improvement on NPH symptom severity scales, gait measures, and cognitive instruments compared to patients lacking pathology. ANN NEUROL 2010;68:535-540
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