Journal
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
Volume 181, Issue 7, Pages 1545-1556Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426500500366285
Keywords
antimicrobial agent; diethyl malonate; ethyl acetoacetate; ethyl cyanoacetate; microwave irradiation; thiopyrano[2,3-b]quinolines
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A series of novel substituted thiopyrano[2,3-b]quinolines 4a-e, 5a-e, and 6a-e were prepared from substituted 3-formyl-2-mercapto quinolines 2a-e , on reaction with ethyl acetoacetate, diethyl malonate, and ethyl cyanoacetate 3a-c by microwave irradiation in the presence of piperidine. Synthesized compounds were evaluated for antimicrobial activities. Among the compounds tested, 7-chloro-2-oxo-2H-thiopyrano[2,3-b]quinoline-3-carbonitrile 6d and 7-nitro-2-oxo-2H-thiopyrano[2,3-b]quinoline-3-carbonitrile 6e were highly active against S. aureus and M. roseus.
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