Journal
DEVELOPMENTAL DYNAMICS
Volume 235, Issue 7, Pages 1962-1973Publisher
WILEY
DOI: 10.1002/dvdy.20811
Keywords
zebrafish; SCNA gene; electrical signaling; Na-v 1 protein; skeletal muscle; cardiac muscle; nervous system; spinal cord
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Funding
- NINDS NIH HHS [P30 NS048154, R01 NS038937] Funding Source: Medline
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Whereas it is known that voltage-gated calcium channels play important roles during development, potential embryonic roles of voltage-gated sodium channels have received much less attention. Voltage-gated sodium channels consist of pore-forming alpha-subunits (Na(v)1) and auxiliary beta-subunits. Here, we report the embryonic and larval expression patterns for all eight members of the gene family (scna) coding for zebrafish Na(v)1 proteins. We find that each scna gene displays a distinct expression pattern that is temporally and spatially dynamic during embryonic and larval stages. Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues.
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