Journal
ANNALS OF NEUROLOGY
Volume 66, Issue 5, Pages 698-704Publisher
WILEY-BLACKWELL
DOI: 10.1002/ana.21799
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Funding
- Deutsche Forschungsgemeinschaft (DFG)
- DFG Transregional Collaborative Research Center 43 The Brain as a Target of inflammatory
- Foundation Of the Multiple Sclerosis Society of Canada
- Medical Faculty of Gottingen
- DFG [GRK 632]
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Research in multiple sclerosis (MS) has recently been focusing on the extent of neuroaxonal damage and its contribution to disease outcome. In the present Study, we examined spinal cord tissue from 30 clinically well-characterized MS patients. MS, amyotrophic lateral sclerosis (ALS), and control spinal cord tissue were subjected to morphometric analysis and immunohistochemistry, for markers of cell damage and regeneration. Data were related to disease duration and age at death. Here, we present evidence for substantial, non-progressive neuronal loss on the cervical and lumbar levels early in the disease course of MS. Chromatolytic neurons and immunoreactivity for c-Jun and GAP43 were observed in the ventral gray matter in and adjacent to actively demyelinating lesions, pointing toward neuronal damage and regeneration as an early response to lesion formation.
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