Journal
ANNALS OF NEUROLOGY
Volume 65, Issue 1, Pages 24-31Publisher
WILEY
DOI: 10.1002/ana.21475
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Funding
- Thyssen Foundation [10.06.1.181]
- Hans und Ilse Breuer Foundation
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Objective: Active or passive immunization of Alzheimer's disease (AD) patients leads to targeting of beta-amyloid plaques by immunoglobulins (IgG) and their subsequent removal by microglia. Here, we investigate whether naturally occurring autoantibodies to beta-amyloid contribute to P-amyloid plaque removal in nonimmunized AD patients. Methods: We generated an AD tissue microarray with 2,325 tissue specimens from 3 defined central nervous system regions of 48 AD patients and 48 age-matched control patients. Absolute quantification of beta-amyloid, beta-amyloid plaque-bound IgG, and phagocytic, resting, and activated microglia and microhemorrhages was done using a standardized, highly reproducible scoring system. Results: The majority of neuritic plaques are decorated by IgG. AD patients with prominently IgG-labeled neuritic plaques have a significantly reduced plaque burden and an increase in phagocytic microglia, yet no increase in microhemorrhages. Interpretation: Autoantibodies directed against P-amyloid are common in AD patients and may contribute in controlling plaque burden.
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