Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 176, Issue 1-2, Pages 16-23Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2006.03.025
Keywords
aluminum; Alzheimer's disease; amyloid beta; copper; neuroinflammation; oxidative stress
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Funding
- NIA NIH HHS [AG-16794, AG18379, AG18884] Funding Source: Medline
- NIEHS NIH HHS [ES 7992] Funding Source: Medline
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Inflammatory and oxidative events are up-regulated in the brain of AD patients. It has been reported that in animal models of AD, exposure to aluminum (Al) or copper (Cu) enhanced oxidative events and accumulation of amyloid beta (A ss) peptides. The present study was designed to evaluate the effect of a 3-month exposure of mice to copper sulfate (8 mu M), aluminum lactate (10 or 100 mu M), or a combination of the salts. Results suggest that although Al or Cu may independently initiate inflammatory or oxidative events, they may function cooperatively to increase APP levels. (c) 2006 Elsevier B.V. All rights reserved.
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