Journal
BIOSYSTEMS
Volume 85, Issue 1, Pages 37-45Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2006.02.004
Keywords
agent-based modelling; chemical interaction; nuclear factor kappa B; signalling pathway
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Individual-based or agent-based models have proved useful in a variety of different biological contexts. This paper presents an agent-based model using a formal computational modelling approach to model a crucial biological system-the intracellular NF-kappa B signalling pathway. The pathway is vital to immune response regulation, and is fundamental to basic survival in a range of species. Alterations in pathway regulation underlie many diseases, including atherosclerosis and arthritis. Our modelling of individual molecules, receptors and genes provides a more comprehensive outline of regulatory network mechanisms than previously possible with equation-based approaches. The model has been validated with data obtained from single cell experimental analysis. (c) 2006 Published by Elsevier Ireland Ltd.
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